After a couple of teases two lickers will leap out of the glass holding tank, which lies just beyond the caged test animals. Sometimes they fake their own death. Aim at them - if there's a red dot it's still alive. If the laser doesn't register the licker, it's dead.
The lickers have poor eyesight, meaning you can creep past them without fear of an attack. They reproduce quickly though. If they hear you you'll be surrounded in seconds. They always attack in large numbers so bigger weapons are recommended for this section.
BOSS GUIDE: U-8
It's relentless in here. Once the vault's elevator is activated, the facility's arachnoid guardian springs to action...
The U-8 appears without warning, and it'll greet you with an instant-death QTE. If you survive, quickly pick up the hand grenade on the platform. Its two main legs have exposed fleshy muscles. Pick a leg and blast it with a powerful weapon (the upgraded shotgun's perfect for this).
Weaken the leg sufficiently and the U-8 will collapse. Now just run to its mouth and toss one of your grenades inside its sticky gob. Two cycles of this and you'll expose its cranium. Now focus all your fire on the brain and you'll send it off to spider heaven.
The only attack to be wary of comes from these flying critters. They trap you in sticky goo, so blast them whenever they appear before attacking the U-8.
You've had it easy up until now. It's here that majini ditch their bottle and knives in favour of some full-blown army gear.
You'll meet these three grunts early on. Run up to the striped crates at the bottom and take cover before trading fire or you'll not get very far. Chapter 5.2 is a good time to invest in the bulletproof vest. From now until the end of the game it's all about using cover to overcome the soldiers.
After the first two rooms there are lots of explosive barrels to use. Strike them and you'll kill half a dozen majini with one bullet. Flash grenades are a pain. Not only do they white-out your screen for two seconds, they remove you from cover. Make sure you don't stray into gunfire when blinded.
FEAR THE REAPER
The reapers are the toughest 'standard' enemies in the game. Thankfully there's one massive chink in their armour.
The first reaper appears once you've restored power to the broken conveyor belt with the test subjects. Run past it and hop on. The reaper will chase you. Stand on the strip between the second and third belts then use the shotgun to knock it over when it gets near.
Normally this tactic would inflict no damage, but this reaper will now slide straight into the furnace. Even it can't survive fire that intense. The only difficulty here comes from the test subjects. If one grabs you just waggle the left stick to shake it off and pick up their treasure afterwards.
Reapers can kill with one-hit, but let them get close and fire one magnum shot into their yellow belly when they're uncovered and they'll go straight down.
BOSS GUIDE: UROBOROS MKONO
The Uroboros is back and, sadly, there's no furnace about to kill him with this time.
Turn around and investigate the flamethrower. This weapon's key, so keep an eye on the five lights above it to monitor the refuelling process. Locate the three gas canisters and knock them over. Everytime the Uroboros swallows one up shoot the canister to set it alight.
When the flamethrower's full pick it up, get in close and go crazy. Fire is the key, either from the flamethrower or the gas canister method. When the Uroboros is on fire it'll change shape and grow bright bulbous targets. These need to be popped, so make sure Sheva's equipped to shoot them.
Alternatively, hand the flamethrower to her and shoot them yourself. Keep one eye on the ammo and be prepared to refuel it.
BOSS GUIDE: WESKER
A scrap with STARS Alpha team leader sounds like fun, but we'd advise you to just run, run, run...