The Game Group is to close a number of its UK Game and Gamestation branches, as well as all Game concessions in Debenhams stores.
The company told Edge that it plans to seek employment opportunities for all 247 affected workers.
Game said in a statement: "We regularly review our entire store portfolio, including our concessions, to maximise the opportunities to reach customers while also ensuring that the business is running as effectively as possible.
"As a result of this review process, and the tougher market conditions that we face in 2010, we have announced our intention to close 12 Game stores, 6 Gamestation stores, and all 25 of our concessions in Debenhams stores. In each location, we have detailed plans to support the customers and employees.
"... With deep regret, we have had to offer redundancy to 247 employees. We will do our utmost to redeploy roles if possible, and have started consulting with all affected employees in the 43 sites."