THQ's further detailed Guillermo del Toro's InSANE, which was announced via a teaser trailer at the VGAs this weekend.
The thriller/horror game - in development at Saint's Row studio Volition - is part of a planned trilogy that will kick off in 2013.
InSANE will deliver "an unprecedented cinematic experience while redefining storytelling in gaming," THQ boldly promises, and del Toro himself reckons the first instalment will bring players to "question their own senses of morality and reality".
Del Toro will serve as external creative director for the games, working closely with THQ core games boss Danny Bilson, director of fiction development Paul DeMeo and Volition, on the development of the trilogy.
In addition, THQ and del Toro will collaborate on potential transmedia projects surrounding the inSANE games, with the director also holding rights to any movie projects based on the IP.
"THQ is committed to creating great games by identifying the world's most talented artists and providing them with the creative support to design innovative game play experiences," said Bilson.
"Guillermo is not only an incredibly gifted writer and film director, but also an avid gamer, and we are excited to bring his talents to our medium. We are confident his unique point of view will create visually stunning adventures, filled with rich and rewarding game play."
Del Toro added: "With this new series of videogames, I want to take players to a place they have never seen before, where every single action makes them question their own senses of morality and reality.
"THQ and Volition, Inc. are equally excited to make this vision of a completely new game universe into a reality."