Nintendo sold 303,000 3DS units across Europe and 113,000 units in the UK during the new portable's first two days on sale.
The figure tops the British launches for Wii and DS, which moved 87,000 units and 105,000 units during their debut weekends.
"Nintendo 3DS allows people to experience, for the first time, 3D technology on the move and at home, with fun and surprises for all to enjoy," said Laurent Fischer, Nintendo of Europe's managing director of marketing and PR.
"With the built-in pick-up-and-play Face Raiders game and StreetPass feature adding new dimensions to the already diverse line-up of launch titles, Nintendo 3DS has struck a chord with gamers old and new."
Nintendo said on Tuesday that 3DS garnered higher day-one sales figures in the US than any previous Nintendo handheld.