Digital Vita titles take a few seconds longer to load than those running off retail game cards, as you can see in the movie below.
Kotaku apparently tested this with multiple games and got the same result on each occasion. Presumably the proprietary memory cards that PS Vita games come on use a faster data transfer rate than the system's flash storage cards.
There is a benefit to digital Vita games though, namely the price. Uncharted: Golden Abyss, for example, costs 5,980 yen (£50) at retail, while the downloadable version costs 4,900 yen (£40).
Our friends at GamesRadar have already got their new portable, and they decided to put together some Vita Welcome and Store walkthrough videos.