THQ is to cut 79 full-time jobs at Texas-based, Darksiders 2 developer Vigil Games and a further 39 positions at Vancouver-based Company of Heroes maker Relic Entertainment.
The publisher said the layoffs are the result of just-announced plans to switch Warhammer 40,000: Dark Millennium from a massively multiplayer online game to a single player and multiplayer title.
THQ said in a statement: "Vigil Games will continue to focus on both this game and the critically-acclaimed new title, Darksiders II, scheduled for release this summer.
"Relic Entertainment continues to focus its development expertise on THQ's franchises including Company of Heroes and Warhammer 40,000: Dawn of War."
Last month THQ announced a net loss of $55.9 million (£35m) for its third fiscal quarter ended December 31, 2011, as well as plans to cut 240 jobs and kill the uDraw brand. It also said CEO Brian Farrell was to take a 50 percent pay cut, reducing his base salary from $718,500 to $359,250, for one year starting on February 13, 2012.