Sucker Punch's open-world action game is Sony's highest profile release of 2014 to date and the company has "high expectations" for the PS4 exclusive.
"We are excited by the level of pre-orders which are exceeding that of The Last of Us at this point in the run up to its launch," SCE UK product manager Josh Walker told MCV.
"We can already see it benefiting from the goodwill and of buzz surrounding the PlayStation 4 and expect Second Son to be the biggest game in the Infamous series to date."
The Last of Us sales topped 3.4 million units between the title's release on June 14 and July 3 last year, making it the fastest selling new franchise in the console's history and, at the time, the quickest selling PS3 game of 2013.
Sony has confirmed an Infamous Second Son release date of March 21, 2014. On Monday, the company said there'll be two digital versions of the game available on the PS Store from midnight on release day: the standalone title, and Infamous Second Son Legacy Edition, which contains the Cole's Legacy DLC.